InthewakeofEamonCunningham’sdeath,theKinsellafamilyisthriving.HoweveranewthreatrearsitsheadwhenmembersofaTurkishcartelinformtheKinsellasthatEamonowedathemsizabledebt–andsincetheykilledhim,thedebtisnowtheirs.Elsewhere,Vikingisreleasedfromprisonintentonmakingtrouble,Amandasuffersapersonaltragedy,andaloomingpresencefrominsidethefamilyreturns.ThenewseasonwillseetheKinsellasatthetopofthegameinDublin,butkillingEamonCunninghamhascreatedasmanyproblemsasitsolved.Theyhaveincurredthewrathofanenemyevenmoredangerousthanhim.Andwhereoncetherewereunbreakablebondsofbloodandfamily,nowthereisonlysuspicion,distrust,andresentment.Butthegreatestthreattothefamilyemergesfromwithin:intheshapeofaruthless,bullying,agentofchaos.Fortunately,frompositionsofgreatadversitytheboldestplansareoftenforged.AndsoitiswiththeKinsellas.ReturningcastincludesCharlieCox(Daredevil),ClareDunne(Herself),AidanGillen(GameofThrones),SamKeeley(JoevsCarole),EmmettJ.Scanlan(PeakyBlinders),MariaDoyleKennedy(Outlander),andYasminSeky.FrancisMageealsoreturnsthisseason.
扬名世界的喜剧演员到家乡费城进行巡回演出，却被迫回答一个问题：为了守护他所拥有的一切，他愿意做到何种地步。
金一趟（葛存壮 饰）是一名拥有着丰富经验的老中医，他的独门秘方“再造金丹”能够治好各种疑难杂症，而金丹的秘方只有金一趟自己一人知道。金一趟有两个女儿金秀（宋佳 饰）和金枝（许晴 饰）。金秀在和张全义（孙淳 饰）结婚后久久没有怀孕，这可急坏了金一趟。一次偶然中，金一趟见到了一名弃婴，收留了他取名金兴。在一连串的意外和波折之后，金秀成为了金兴的养母。 金枝结识了名为徐伯贤（马红鹰 饰）的男子，徐伯贤经营着一家公司，一心想要得到再造金丹的配方，将它批量化生产以获得巨大的利益。再造金丹的存在让众人纷纷被卷入了阴谋和感情的漩涡之中。