比历史上任何的震颤、愉悦、高潮都强烈51倍的蓝色化合物，2千万的交易，为蓝色药丸疯狂的城市。这一切都开始于1971年，艾尔默·麦科尔罗伊(萨缪尔·杰克逊)毕业的当天，在开车回家的路上吸大麻被当场擒获，于是一眨眼的功夫，他的药剂师执照之梦，象他手里的青烟一样飘散了……
一次偶然中，海伦（海伦娜·伯翰·卡特HelenaBonhamCarter饰）和玛格丽特（艾玛·汤普森EmmaThompson饰）两姐妹结识了威尔克斯一家人。在威尔克斯家所拥有的霍华德庄园中，玛格丽特和威尔克斯太太（瓦妮莎·雷德格瑞夫VanessaRedgrave饰）的感情最为要好，海伦却在和保罗（JosephBennett饰）的一段短暂恋情结束后离开了威尔克斯家。威尔克斯太太死前将整个霍华德庄园留给了玛格丽特，亨利（安东尼·霍普金斯AnthonyHopkins饰）隐瞒了这一事实，转而向玛格丽特求婚。离开了霍华德庄园的海伦遇见了名叫巴斯特（SamuelWest饰）的男子，两人相处融洽。玛格丽特再度见到海伦之时，她震惊的发现，尚未成家的海伦已有身孕，这样的海伦遭到了威尔克斯家大儿子查尔斯（詹姆斯·维尔拜JamesWilby饰）的厌恶和驱逐。
Sometime in the near future, paraplegic prison inmate Matt Mills meets "The Board" of Satoshi-Telefair Industries, who thank him for joining the Program. Under pressure and with a promise to make him walk again, Mills agrees to volunteer. He is injected with a synthetic nanomaterial and suffocated, only to wake up with restored use of his legs, yet alone in a steel cell in the first spoke of an experimental apparatus - The Wheel. A series of assailants inflict a multitude of damage to Mills' body and torment his mind, yet the synthetic nanomaterial not only restores his damaged organs, it re-engineers his strength. The experiment might be designed to kill, but Mills is determined to survive - and get back to his daughter before The Board finds her first.
太虚幻境——与人类现代社会平行的异世界，在那片广袤的土地上生活着人、佛、神、魔四族。佛族的三藏法师因为与女儿国国王约会而受到佛族与神族的诛杀，他的弟子齐天、天蓬、悟净为了保护师父，不惜与诸神开战！